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The principal cytochrome P450 isoenzyme involved appears for being CYP2E1, with CYP1A2 and CYP3A4 as added pathways. About eighty five% of the oral dose seems inside the urine in just 24 hours of administration, most because the glucuronide conjugate, with smaller quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity info.